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Researchers say the findings underscore the need for continued monitoring of prescribing trends and for larger randomized clinical trials evaluating whether leucovorin is beneficial for specific groups of children with autism

General laboratory research protocols

Differential oxylipin abundance analyses were conducted using limma, which fits a linear model to data from each lipid using empirical Bayes smoothing to improve estimates of standard errors of log fold changes 37 , and calculates Benjamini-Hochberg (BH) false-discovery rate p-values for each lipid 38

10.1128/JB.01616-08 32 ClarkeS

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