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Gao Y, Martin NI, Van Haren MJ (2021) Nicotinamide N -methyl transferase (NNMT): an emerging therapeutic target
Their primary benefit is that they provide a boost of energy and prevent fatigue, improving overall cognitive functioning including memory, and cognitive performance, and even helping with weight loss

It is an intracellular metabolic-enzyme modulator, which is why its research read-outs are things like NAD+ levels and adipocyte gene expression, not how full you feel. That mechanistic distinction is the single most important thing to understand before looking at any dose number

Very high doses (such as those used for cyanide poisoning) should be used with caution and only if the potential benefit outweighs the risk

Vitamin B12 is water soluble which means your body will excrete any of the vitamin it does not need
