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5-Amino-1MQ binds the NNMT active site at low micromolar Ki, producing selective inhibition relative to other SAM-dependent methyltransferases [1]

Intramuscular injections may be preferred for deeper absorption , while subcutaneous options may offer ease of use in at-home settings when clinically appropriate

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When it comes to supplements, taking high doses of vitamin C at the same time as your B12 shot might slightly lower the amount of B12 your body can use, but this is more relevant for oral B12 supplements than injections