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BAG-1M co-activates BACE1 transcription through NF-B and accelerates A production and memory deficit in Alzheimers disease mouse model

It has been shown that SLC7A11 antagonizes glutamine metabolism [53] and that glutaminolysis, a mitochondrial process that converts glutamine to metabolites to fuel the tricarboxylic acid (TCA) cycle, is required for the execution of ferroptosis [54]

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Optimizing such schedules to carefully balance tumor control while avoiding toxicities remains a vital area for ongoing clinical investigation