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On the molecular level, Akt activation is part of the cell survival response
Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases

In terms of endogenous antioxidant defenses, sucrose and aspartame significantly reduced the activities of key antioxidant enzymes, including SOD, CAT, GST, and GPx, confirming an oxidative burden on neural tissues

10.1016/j.freeradbiomed.2013.05.027 [DOI] [PMC free article] [PubMed] [Google Scholar] Gallegos-Arreola M

This extreme form of ventilation-perfusion mismatch results in impaired alveolar gas exchange , leading to poorly oxygenated blood returning to the systemic circulation and causing hypoxemia
