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Low cortisol impairs the body's ability to fight the infection

further modified the anterior model by intradiscal injection of saline into rat lumbar IVDs, which resulted in increased pain, as evaluated by increased grooming duration, decreased mechanical withdrawal thresholds, and decreased thermal withdrawal latency

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The effect of the endogenous transmitter, dopamine, is to inhibit the release of acetylcholine (ACh), and this results in decrease in motility of the stomach and proximal small bowel (Tonini et al., 2004)