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In the COG AALL0932 (NCT01190930) trial, NCI standard-risk patients with average-risk features were randomly assigned to receive weekly oral methotrexate during maintenance at one of two starting doses: 20 mg/m2 (standard) or 40 mg/m2 (investigational).[115][Level of evidence A1] There was no significant difference in 5-year DFS from the start of maintenance therapy between the two treatment arms (5-year DFS rate, 95.1% for patients who received the standard dose vs

7c, and Supplementary Figs

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mPFC: 22 ASD (2F/20M) and 21 TDC (6F/15M)

Previous studies have shown the effect of guanidine as a ligand on the palladium reactivity in Suzuki cross-coupling reaction under aqueous conditions 37