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However, it differs from other forms of PCD in that ferroptosis is based on divalent iron and leads to cell death by promoting lethal accumulation of intracellular lipid peroxides [12]

The stimulated astrocytic GSH export induced by these compounds is prevented by inhibition of Mrp1, demonstrating that this transporter mediates the druginduced stimulated GSH export, while the basal GSH export is only inhibited by around 60% in the presence of the Mrp1 inhibitor MK571 (Hirrlinger et al

The questionable association of vitamin e supplementation and mortality--inconsistent results of different meta-analytic approaches

doi: 10.1083/jcb.200507087

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