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Severe pain, swelling, weakness, numbness, fever, unexplained weight loss, blood in stool, persistent vomiting, chest pain, or neurological symptoms should not be managed through peptides or supplements

doi: 10.1073/pnas.1101424108

Essentially the injection may be a temporary measure to fix levels

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The highest NAD+ levels are found in neonates, and they gradually decrease with increasing chronological age (6)