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En contraste, durante la hemodilisis (100 mL/min), la L-carnitina se disminuye en el plasma aproximadamente en un 80% al final de cada sesin.10 Esta reduccin en el plasma se debe a que la sntesis endgena se ve alterada durante la hemodilisis, as como a la deficiencia de algunos cofactores (vitamina B6, niacina, vitamina C y hierro) que son necesarios en la ruta enzimtica encargada de sintetizar carnitina

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A randomized placebo-controlled trial involving intravenous infusion of allogeneic adipose-derived MSCs reported no significant improvement in serum creatinine levels, although an upward trend in quality-of-life indicators was observed (129)