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These combinatorial strategies aim to create a permissive TME that supports robust T-cell infiltration, thereby overcoming a foundational bottleneck to effective antitumor immunity

[,,] In turn, the skeletal muscle also influences hepatic homeostasis and diseases partially by myokine [Figure 8b]

As we age, GH levels decline leading to slower recovery, increased belly fat, low energy, and reduced muscle tone

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Heat shock proteins such as HSP70 which have stress-inducible expression and function as protective agents against cellular oxidative stress and inflammation, are found at elevated levels at sites with lipid accumulation (oxidized low-density lipoprotein) and activated macrophages, such as during the development of atherosclerotic plaques [68]