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Exposure to ROS leads to oxidation of thiol groups of key cysteine residues in many proteins including kinases, phosphatases and transcription factors

Although biliary excretion of 1,2-DCP has never been reported, both depletion of hepatic GSH 11 and urinary excretion of mercapturate form of 1,2-DCP (an ultimate metabolite of GSH-conjugates) 12,13 are observed in 1,2-DCP-administered rodents, supporting that GSH is conjugated with 1,2-DCP

This type of damage can occur during shock and surgery or transplantation of these organs

Progress in Biosynthesis, regulation and Metabolic engineering of plant terpenoids

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