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Description
Severe cases * Liver transplant (can be life-saving) * Autosomal recessive inheritance * Low ceruloplasmin + high urinary copper * Neuro + liver + psychiatric triad * KayserFleischer rings = classic sign Why it matters If untreated, Wilson disease can be fatal
PMID 8717520
DOI 10.1096/fj.10-174078
Cell-culture (3T3-L1 adipocytes) 5-Amino-1MQ at 30 M strongly reduced 1-MNA levels in mouse fat cells, confirming NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)
21 Additionally, glutathione serves as a regulatory compound in the activation of the circulation agents of the immune system, lymphocytes
