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The controls simultaneously received an equivolume of saline (5.0 ml/kg ip) or water only (12 ml/rat/day)

Tip The so-called Holo-TC value (Holo-Transcobalamin), which measures the actual amount of vitamin B12 available in the body, is particularly meaningful in this context

MOTS-c, by contrast, works from the inside of the mitochondria outward, activating the same primordial energy-sensing cascade that millions of years of evolution have refined into the body's most fundamental metabolic regulator

When stratified by administration route, the mean percentage changes were: Intramuscular (IM): 307% Oral: 285% Sublingual: 199% IM administration showed the highest average B12 increase, although oral and sublingual routes also yielded substantial improvements, supporting their use as effective and less invasive alternatives

its impact on the health-related quality of life (HRQL)