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Description
Protocatechuate is then ring-cleaved by either the ortho (3,4-dioxygenase) or meta (4,5-dioxygenase) pathway, generating -carboxy-cis,cis-muconate or its meta-cleavage analogue, which feed through -ketoadipate or pyruvate/oxaloacetate intermediates into the TCA cycle
doi:10.1002/cbf.1149
In contrast, ectopic expression of ARG2 inhibits the proliferation of ccRCC by selectively depleting the PLP but not its precursors, PN and PL, and induces broad metabolic reprogramming
In their study, Chen et al
10.1124/pr.117.014092 Pharmacol Rev
