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Beta subunits have tyrosine kinase domains, whose activation is mediated by the binding of IGF-1 to alpha subunits, and it is associated with various signaling pathways, including PI3K/Akt and Raf/MEK/ERK cascade (37, 38) ( Figure 2 )

Overall, these results demonstrated the pivotal role of IGF-1 in enhancing cell proliferation and migration

Am J Hum Genet 34(3):425433 Moura FA, de Andrade KQ, Dos Santos JCF, Arajo ORP, Goulart MOF (2015) Antioxidant therapy for treatment of inflammatory bowel disease: does it work

Although aging does not inherently alter individual hematopoietic stem cells (HSCs), it does shift the clonal composition of the HSC pool

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