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With this premise, in the 1970s, Bystrm proposed procarbazine for the treatment of PD, but subsequent studies did not reveal any objective benefit

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Results Surrogates of propionate metabolism are raised in PA mice Propionyl-CoA is generated in mitochondria and can be processed to derivatives, including propionyl-carnitinea commonly used surrogate 26 (Fig

Woolhouse, Scott A

Another important limitation relates to the fragility of this patient group and the difficulty of adhering to such a restrictive diet
