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Moreover, they have been reported to promote cartilage regeneration in OA and play a role in harmful processes such as osteophyte formation and inflammation, which further exacerbate cartilage degradation (Fig

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Leveraging the cartilage matrix as a drug reservoir while minimizing potential systemic toxicity holds particular significance in addressing the chronic nature of OA and its high prevalence of comorbidities

Thirdly, GLP-1 agonists slow gastric emptying, leading to a delayed absorption of nutrients and a prolonged feeling of fullness, which can contribute to reduced food intake and weight loss