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The polyol pathway works as the most important source of ROS generation in the neuron, retina, and nephron, and sorbitol increase concentration has been associated with neuropathy, retinopathy, and nephropathy of DM (Figure 4) (Eckers et al., 2012

Methodologically rigorous studies that couple pathway inhibition to predefined immune and clinical endpoints, deploy standardized biospecimen workflows and use harmonized safety reporting are required to determine whether neurotrophin-targeted strategies can remodel the osteosarcoma microenvironment toward durable immune control

J Alzheimers Dis 19:311323

PMID: 25535733

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