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Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinsons disease

Some cytosolic GSH is transported, thanks to a specific transporter, the multidrug resistance protein 1 (MRP1), out of the cell to maintain a balance in the redox level [22], or can be conjugated by GSH transferases (GST) with endogenous metabolites, such as cysteinyl leukotriene or xenobiotics (therapeutics, anticancer drugs, carcinogens, pesticides, herbicides), forming a complex GSH-Xen, which is transported outside the cell by MRP1 [19]

We found no differences between the preparation conditions tested nor an effect of time to deproteinization on stability of total GSH, suggesting that use of either heparin or EDTA during sample collection can prevent enzymatic degradation of GSH when samples are stored at 80 o C

(2017) 356:eaaj2239

6ce and Fig S6kl)