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Sulfate conjugation reactions catalyzed by SOT generate 3-phosphoadenosine 5-phosphate (PAP), a molecule that participates in the organelle-nuclear retrograde signaling, if not dephosphorylated by the SAL1 phosphatase (Estavillo et al., 2011)

doi: 10.1093/nar/gkv679 297 WatanabeM.Dykes-HobergM.Cizewski CulottaV.PriceD

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Specifically, SIRT1 transferred via CAA-EVs promotes an increase in M2 macrophages, which are known for their immunosuppressive and tumor-promoting roles

Copper efflux transporters ATP7A and ATP7B: novel biomarkers for platinum drug resistance and targets for therapy