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Further characterization showed reduced PAI-1 fluctuation in Clock mutant mice while Cry1/2 -deficient mice held similar levels at both 0900 and 2100 h (Ohkura et al., 2006)

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Experimental evidence from knockout models suggests that reduced NNMT activity is associated with resistance to tumor formation, leading to speculation about a possible role for this enzyme in cancer biology

Dose-dependent effects of corticosteroids on the expression of matrix-related genes in normal and cytokine-treated articular chondrocytes