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The combination of metformin and apigenin synergistically modulates the HGF/MET signaling pathway, inhibits METmediated invasion, and influences downstream pathways such as PI3K/AKT, offering an innovative approach to enhance the efficacy and outcomes of cancer treatment [280]

SF also induces anti-inflammatory, heat shock-response (HSR)-inducing, and histone deacetylase (HDAC) inhibiting responses, contributing to its multifaceted cytoprotective effects (2, 13)

The ontogeny of drug metabolizing enzymes and implications for adverse drug events

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Future research should actively focus on preclinical evaluations using large animal models, such as pigs, dogs, and non-human primates, systematically assessing the safety, pharmacokinetic characteristics, and therapeutic effects of exosome therapies under more human-like anatomical and physiological conditions