low glutathione toxins - an overview Lowering glutathione level by buthionine

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Immunopharmacol Immunotoxicol 2003;25(2):25971.ArticlePubMed [38] Ben-Arie E, Lottering B, Inprasit C, Yip HT, Ho WC, Ton G, et al

Furthermore, NMDS analysis reinforces this finding, showing that the points representing the three samples are tightly clustered, indicating a high degree of similarity, while the gut sample is distinctively separated, highlighting significant differences in species composition

Furthermore, histopathological observations on both H & E staining and Oil red O staining demonstrated serious hepatic steatosis and cardiac tissue damage with lipid droplets in HM groups contrasted to the control group due to higher lipid profile and increased cellular toxicity marker such as ALT, AST, ALP, LDH and CK-MB level

Currently, commonly used rat models for constructing MASLD diseases in laboratories include Wistar rats, SD rats and Zucker rats (Table I)