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Under physiological conditions, ROS production by the NOXes prevails

It remains unproven whether the differing molecular signatures are due to the route (bypassing the blood-brain barrier vs
Qi Y, Zhao W, Li M, Shao M, Wang J, Sui H, et al

B12 deficiency [86] is associated with lower glutathione levels

and fully differentiated (TH +) DA neurons through removal of DNA methylation and the repressive histone code (H3K9m3, H3K27m3) (Wulansari et al., 2017)
