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Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina (Benca)

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Considering that insulin resistance is regarded a hallmark of NAFLD progression closely linked to inflammation, oxidative stress, and disease progression [54-56], an additional benefit of a LCD in NAFLD is reasonable from a pathophysiological perspective

Pro-inflammatory cytokines, glutamate and reactive oxygen species such as peroxynitrite and superoxide radicals are produced in the injured spinal cord tissue leading to axonal swelling, myelin breakdown, inflammation and mitochondrial dysfunction followed by apoptotic death of neurons and glial cells [3][6]

doi: 10.1097/HCR.0b013e3182122827