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A remarkable decline in the loss of neurons has also been found in CA1 and CA3 regions of the hippocampus [65]

FIGURE 3 Further, emerging evidence has indicated that copper stabilizes the HIF-1 protein through inhibiting prolyl hydroxylases-mediated prolyl hydroxylation in an iron-independent manner, which is required for transcriptional activation of HIF-1 of a series of target genes (Martin et al., 2005

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