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[2] While steroid hormones are produced mainly in vertebrates, the physiological role of the HPA axis and corticosteroids in stress response is so fundamental that analogous systems can be found in invertebrates and monocellular organisms as well

The antioxidant effects of vitamins and minerals are also concentration-dependent and context-specific, with potential for pro-oxidant effects at very high doses

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Psychiatry 60 (7), 704713