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The authors provided detailed insights into the chemical mechanisms, application protocols, and the comparative advantages of different probe types, underscoring the need for accurate and biologically relevant detection systems

Improved erastin analogs, such as piperazine erastin (PE) [24] and imidazole ketone erastin (IKE) [83] may be useful as in vivo probes of tumor susceptibility to ferroptosis

These free radical and oxidative stress can cause damage and the mitochondria in the process rendering them not being able to function and provide the needed cellular energy for the body to function optimally

This discouraged the pharmaceutical industry from developing such drugs and undermined the FDA's willingness to approve them

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