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No study has tested these three together in animals or humans, so the synergy is reasoned from mechanism, not measured

Severe vitamin B12 deficiency in pregnancy mimicking HELLP syndrome. Case Reports in Obstetrics and Gynecology 2019 (2019)

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Second, the C677T and A1298C variants are very common: in some ethnicities, more than 50 percent of people have at least one copy of one of these variants