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The first draft of the manuscript was written by TP and RJK, and all authors commented on previous versions of the manuscript

coli suppressor mutants were found to carry an expanded triplet repeat in the gene encoding alkyl hydroperoxide reductase C (AhpC), which encodes a Trx- and GSH-independent peroxidase (Fig

Although it remains unclear whether barrier dysfunction precedes disease or results from active inflammation, increased intestinal TJ disruption is observed in IBD patients suggest that dysregulation of TJ barrier integrity may predispose or enhance IBD progression

for example, Mycobacterium tuberculosis can modulate host mitochondrial metabolism to reduce oxidative stress and support intracellular persistence, while Chlamydia trachomatis alters host energy metabolism to maintain a favorable niche for replication (Mohareer et al., 2020