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These abnormalities disrupt neuronal communication, leading to atrophy in areas such as the hippocampus and the neocortex, critical areas for learning and memory [70]
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In order to protect itself, the body utilizes an antioxidant defense mechanism that includes both enzymatic and non-enzymatic ways to remove ROS
however, several class III studies have shown the minerals magnesium and zinc to be most effective at improving both pre-clinical and clinical TBI outcome
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