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Thus, in patients with MM presenting with AKI, other causes of renal failure such as dehydration, hypercalcemia, drug-induced nephritis, unrelated diabetes or hypertension, and other monoclonal gammopathy related renal pathology must all be excluded

In addition, the reaction leads to the racemization of isoAsp residues and the C-terminal amino acids, generating both l- and d-forms, and thus could complicate the LCMS profiles and data interpretation

Wainberg ZA, Han S, Lee S, Lee K, Kopetz S , Mizrahi J, Hong YS, Ghiringhelli F, Italiano A, Tougeron D, Beagle B, Boakye M, Zhao T, Rhee J, A Nuyten DS, Cecchini M

Additionally, photoreceptor segment thinning, a process involving a shrinking of the photoreceptor retinal layer, occurs as early as age forty and progresses linearly with age [40]

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