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High levels of SAMe will in turn drive catecholamine COMT metabolism (Figure 4) Therefore, in such a flavin-sufficient, methylating state, there is a theoretical risk that catecholamines will be excessively degraded by both MAO and COMT to a degree that depleted catecholamine levels lead to depression and adrenal re-synthesis exhaustion with cognitive and motor retardation (109)

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18 and the results from this study (Fig

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2015) and vitamins (Liao et al

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