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Studies indicate that under hypoxic conditions, the degradation of HIF-1 is inhibited, causing it to accumulate in the cytoplasm

To overcome problems in folding during de novo production, a truncated version of AcK1 (AcK1t) was designed lacking the first nine N -terminal residues, and an analog of BmK1 (BmK2) was designed based on the ShK-channel interaction surface, differing from the native peptide by five residues

In: Khalida Ismail and others (eds), Depression and Type 2 Diabetes (Oxford,

V., Chuong, C

In addition, orofacial nerve injury (IONI) induced neuropathic pain can up-regulate the IGF-1, while subcutaneous injection of IGF-1 neutralizing antibody can recover the mechanical head withdrawal reflex thresholds (MHWTs) significantly[76]