Methylation cycle hypothesis
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Nat Chem Biol 9:693700
The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable
Its approved by the FDA and sold under brands like Ozempic, Wegovy, and Rybelsus
10.1111/j.1365-2214.2007.00751.x [DOI] [PubMed] [Google Scholar] 44
