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10.1007/s00109-015-1310-2 115 RobertiA.FernndezA

248.Ravussin E, Smith SR, Mitchell JA, et al

Simultaneously, higher S-adenosylmethionine (SAM) availability supports key methylation-dependent pathways, which are crucial for epigenetic regulation and gene expression related to energy metabolism

NHS loading is 1mg hydroxocobalamin every two days for two weeks, then maintenance every two to three months for life when the cause is non-dietary
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