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Aminesincluding arginine, proline, and methionine sulfoxidewere upregulated while serotonin and sarcosine were downregulated, suggesting an SSRI effect on urea cycle, one-carbon metabolism, and serotonin uptake

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A common estimate is TBW [(Serum Na / 140) 1] , where TBW 0.6 weight (kg) for men and 0.5 for women (adjust for age/comorbidities)
