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Exposure to PS-NPs and PS-MPs promoted ferroptosis in cardiomyocytes and endothelial cells by upregulating pro-ferroptotic ACSL4 and downregulating antioxidant enzyme GPX4, leading to ROS accumulation, mitochondrial membrane depolarization, and reduced cell viability [19, 178, 179]

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Since compulsive behaviour in OCD has been postulated to emerge from an imbalanced cortico-striatal circuitry favouring the habit system we hypothesised that this might be reflected in neurochemical imbalances in the anterior cingulate and SMA

L., Siwak, E

213,214 The structure of KDM5A contains three PHD domains, especially, the PHD1 domain in KDM5A can preferentially recognize unmethylated H3K4 histone tails and stimulate its activity (Fig