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Am J Geriatr Psychiatry 2004

Finally, systemic metabolic conditions such as diabetes, aging, and obesity introduce additional complexity by altering baseline oxidative tone, mitochondrial resilience, and inflammatory sensitivity

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This review systematically summarizes the functional mechanisms of key signaling regulators involved in cancer metabolic reprogramming, including mammalian target of rapamycin complex 1 (mTORC1), myelocytomatosis viral oncogene homolog (c-Myc), hypoxia-inducible factor-1 (HIF-1), activating transcription factor 4 (ATF4), nuclear factor erythroid 2related factor 2 (NRF2), and sterol regulatory elementbinding protein 1 (SREBP1)