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Meta-analysis of these datasets indicates that the excess CHD risk in TT homozygotes compared to CC homozygotes was 2% (much lower than predicted from the prospective observational studies), a nonsignificant difference (that is, it could have occurred by chance)

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One study showed that women with the lowest B12 levels were five times more likely to have a child with a neural tube defect

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Oral B12 supplements require daily intake and have much lower bioavailability only about 1 to 2% is absorbed without intrinsic factor.