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In regard to eNOS function, 5-methyltetrahydrofolate (MTHF), the active form of folic acid, does not have an effect on pterin-free eNOS, but directly interferes with BH 4 -repleted, partially uncoupled eNOS, shifting it from superoxide production toward NO production (Stroes et al., 2000)

doi: 10.1016/j.niox.2021.04.003 61 GhasemzadehMGhasemzadehAHosseiniE

Trubitsin et al., 2014)

(f) All antioxidant results should be presented in a single international system of units (SI)

Thus, intestinal absorption emerges as a critical factor limiting EGCG bioavailability and its potential neuroprotective effects across the BBB