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doi: 10.1038/s41467-020-15068-4 102 SpadoniIZagatoEBertocchiAPaolinelliRHotEDi SabatinoAet al

The benefit of HIPEC depends on the capacity of drug-exposed tumour cells to regenerate after drug washout

Saturday, November 22, 2025 1:30pm - 4:00pm Health Sciences Oral Presentations Section Meeting opens at 1:30 First Author Jennifer Clark Morehead State University Fusion imaging enhances lesion detection accuracy by combining two imaging modalities

It also complements vitamin E, which helps reduce the oxidation of unsaturated fatty acids, supports the integrity of cell membranes, promotes the health of skin and blood cells, and helps lower free radical formation with its antioxidant effects

ATF4, a transcriptional activator of ASNS, is upregulated when TP53 deleted, leading to increased ASNS expression and increased intracellular asparagine synthesis ( GLS1 (GAC, glutaminase C), such as CB-839 and DONs, suppress glutamine metabolism, mainly by affecting GDH in the active site of GAC reducing its conversion to glutamate and thus limiting the synthesis of asparagine