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Sikiric et al., 2006)

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Myo-Inositol for Fertility and PCOS Deep dive into the most-studied PCOS supplement, including the 40:1 ratio rationale and clinical evidence

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10.1097/00001199-200208000-00004 J

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Upon release, Nrf2 translocates to the nucleus where it can bind to the antioxidant response element (ARE) located in the promoter region of genes coding for antioxidant enzymes and scavengers

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However, it was not recognized at the time that evidence for the protein binding hypothesis was obtained in animals on a normal diet whereas the LPO hypothesis was derived from animals fed a vitamin E-deficient diet high in polyunsaturated fatty acids (PUFAs), i.e., in animals highly susceptibility to LPO [61]

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