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Its postulated that its antimelanogenic properties result from a variety of mechanisms including stimulation of pheomelanin synthesis rather than darker eumelanin, its antioxidant effects, and interference with intracellular trafficking of melanin-causing enzymes

As an initial step, attention was directed toward cocrystals and amorphous solid dispersions

Consequently, it was easy to establish those food sources that contained such vitamins, since they relieved or prevented the relevant syndromes (1,2)

In 2014, the US Food and Drug Administration (FDA) acknowledged a GRAS (Generally Recognised as Safe) notification for AOD 9604 as a food ingredient meaning the FDA raised no questions about the notifier's own safety conclusion

Furthermore, the intracellular ROS level was detected by ROS probes