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In CRC cells, the mutant isocitrate dehydrogenase 1 inhibitor Ag120 inhibited ASCT2-mediated Gln uptake, leading to decreased cell proliferation and increased oxidative stress both in vitro and in vivo [63]

In MR, genetic variants are applied as instrumental variables (IVs) to access the potential causal relationship between exposure and outcome due to the random distribution of these variants during meiosis ( Materials and methods Study design An overview of the bidirectional and unidirectional two-sample MR designs is presented in Figure 2

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doi:10.1182/blood.V92.7.2471

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