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Metabolic profiling, enhanced by PCA and orthogonal partial least squares discriminant analysis (OPLS-DA), demonstrated a clear metabolomic divergence between the WT and GR mutant strains (Figure 5A), indicating the significant impact of GR knockout on the metabolic framework

Cappuzzo, F

Comment Spontaneous and xenobiotic-induced cystic degeneration/spongiosis hepatis may occur in rats (Karbe and Kerlin 2002

these effects are generally dosedependent

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