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NAC has multiple protective mechanisms, including: increasing glutamate transport into glial cells, increasing extra-synaptic glutamate release via activation of mGlu2/3, and antioxidant effects as the precursor to glutathione [214]

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Research has also revealed that effector CD8+ T cells characterized by high expression of granzyme K (GzmK) and low expression of granzyme B (GzmB) and perforin have relatively weak cytotoxic effects, driving the development of LN inflammation through the secretion of cytokines (207, 212, 213)