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(2) Warmth-activated neurons (WANs): PACAP/BDNF+ VMPO neurons primarily driven by peripheral afferent thermal signals and activated by warmth stimulation
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Plasma concentrations fall from approximately 200 ng/ml at age 20 to around 80 ng/ml by age 60
While BDNF supports plasticity via TrkB, proBDNF can activate p75 receptors and trigger apoptosis [67, 349]
