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They found that at the dose of 0.2% for 6 weeks, CPZ could induce complete demyelination in the corpus callosum while having no detectable toxic effect on the peripheral organs such as the liver and causing only mild weight loss in the mice

Consequently, the incorporation of multiple drugs within a single nanoparticle has the potential to enhance the potency of the mixture, thereby improving its antimicrobial efficacy and the likelihood of overcoming existing resistance mechanisms in microorganisms [251]

Liu HT and Kuo HC: Intravesical botulinum toxin a injections plus hydrodistension can reduce nerve growth factor production and control bladder pain in interstitial cystitis

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The validated path comes first: sleep hygiene, cognitive behavioral therapy for insomnia (CBT-I), evaluation for an underlying sleep disorder, and established interventions such as melatonin where appropriate